Introduction
Hyaluronic acid (HA) is an essential component of synovial fluid, known for its powerful viscoelastic properties that lubricate and cushion joints. For decades, HA injections-commonly known as viscosupplementation-have been used to relieve pain and restore mobility in patients with osteoarthritis (OA). Traditionally, hyaluronic acid was extracted from animal sources such as rooster combs. However, with advances in biotechnology, microbial fermentation–derived HA has become the new industry standard.
This article compares rooster comb hyaluronic acid with microbial fermentation hyaluronic acid, highlighting why Singjoint® Medical Sodium Hyaluronate Gel-developed by Singclean Medical-is the safer, more effective choice for modern joint care.
Rooster Comb Hyaluronic Acid: Traditional Source
Historically, hyaluronic acid was extracted from rooster combs, where HA occurs naturally in connective tissue. This source provided an effective way to produce therapeutic-grade HA in the early years of viscosupplementation. However, the animal-derived process presents several limitations:
- Allergic reactions and immunogenicity: Since rooster comb HA contains residual animal proteins, it carries a risk of allergic responses or inflammatory reactions in sensitive patients.
- Complex purification steps: Removing animal proteins and endotoxins requires multiple chemical treatments, potentially affecting HA stability and molecular integrity.
- Ethical and contamination concerns: The use of animal tissues raises concerns about cross-species contamination and disease transmission.
While rooster comb HA remains in use for some legacy products, it is increasingly being replaced by non-animal, biotechnology-based alternatives due to these safety and ethical concerns.
Microbial Fermentation Hyaluronic Acid: The Modern Biotech Solution
In contrast, microbial fermentation HA is produced by fermenting non-pathogenic bacterial strains-most commonly Streptococcus zooepidemicus-under controlled conditions. This advanced method offers several key benefits:
- Non-animal origin: Completely free from animal proteins, making it suitable for all patients, including those with allergies or ethical concerns.
- High purity and consistency: Fermentation technology ensures uniform molecular weight and concentration for predictable therapeutic performance.
- Better biocompatibility: With osmolality closely matching that of human synovial fluid, microbial HA integrates smoothly into the joint environment without irritation.
- Environmentally sustainable: This process is cleaner and more reproducible than animal extraction.
Microbial fermentation has thus become the global gold standard in medical-grade hyaluronic acid production-especially for sensitive applications like joint injections and ophthalmic surgery.
Why Singjoint® Stands Out
Singjoint®, developed by Hangzhou Singclean Medical Products Co., Ltd., exemplifies the highest quality in microbial fermentation hyaluronic acid for osteoarthritis management. Manufactured under strict Class 10,000 cleanroom standards, Singjoint® provides long-lasting pain relief with superior safety and comfort.
Key Advantages of Singjoint®:
- High Concentration and Molecular Weight: Singjoint® HA features a molecular weight of up to ≥1.6M Daltons and a concentration of up to 20 mg/ml, creating an optimal viscoelastic environment that enhances lubrication, cushions joints, and delays cartilage degeneration.
- Superior Biocompatibility: With an osmolality of 313 mOsm/kg-closely matching human synovial fluid-Singjoint® minimizes discomfort during injection and ensures smooth integration into the joint.
- Extended Pain Relief: Thanks to its high viscosity and molecular stability, a single Singjoint® injection provides relief for up to six months-significantly longer than many rooster comb–based alternatives.
- Safe, Non-Animal, and Environmentally Friendly: Produced through microbial fermentation, Singjoint® avoids animal-derived impurities and immunogenic risks, making it a biocompatible and sustainable choice for long-term osteoarthritis treatment.
Clinical Effectiveness and Patient Comfort
Clinical evidence shows that exogenous HA supplementation enhances endogenous HA synthesis, promotes cartilage protection, and reduces inflammatory mediators in OA. The high purity and biocompatibility of Singjoint® enable it to achieve these therapeutic effects more efficiently than traditional rooster comb products.
Patients report improved mobility, longer pain-free intervals, and higher comfort levels following Singjoint® injections, reflecting its optimized formulation and patient-centered design.
Conclusion
While rooster comb hyaluronic acid played a vital historical role in joint therapy, microbial fermentation hyaluronic acid has clearly surpassed it in safety, consistency, and biocompatibility. As a leading example of this technology, Singjoint® Medical Sodium Hyaluronate Gel from Singclean Medical provides long-lasting relief and supports joint regeneration with unparalleled purity and performance.
For orthopedic professionals and patients seeking non-animal, effective, and biocompatible joint care, microbial fermentation HA-especially Singjoint®-is the superior choice.
About Singclean Medical
Hangzhou Singclean Medical Products Co., Ltd. is a manufacturer of absorbable biomaterials and medical hyaluronic acid products. With over 20 years of innovation in regenerative medicine, Singclean focuses on high-quality, EU-standard-certified solutions for orthopedics, ophthalmology, and aesthetics. Its flagship viscosupplementation product, Singjoint®, combines advanced biotechnology with patient comfort to deliver reliable and lasting relief from osteoarthritis pain.