Medical Sodium Hyaluronate Gel

 

Helping Millions of Osteoarthritis Patients Regain Mobility Without Surgery

As populations age and obesity rates continue to rise worldwide, knee osteoarthritis (OA) has become one of the most common causes of chronic joint pain and disability. Millions of patients experience persistent knee pain, stiffness, swelling, and reduced mobility, which can significantly affect daily activities and quality of life.

While oral pain medications and physical therapy may provide temporary relief, many patients continue to seek effective non-surgical treatment options that can help restore joint function and delay the need for knee replacement surgery. This growing demand has driven the widespread adoption of hyaluronic acid knee injections and viscosupplementation therapies in orthopedic practice.

Singjoint® Sodium Hyaluronate Intra-Articular Injection is developed to address these clinical needs by replenishing joint lubrication, reducing friction within the knee, and helping relieve osteoarthritis-related pain. As a trusted solution for knee pain management, Singjoint® supports improved mobility and enhanced patient outcomes while offering healthcare providers and distributors a reliable, high-quality viscosupplementation product.

What Is Osteoarthritis (OA) of the Knee?

OA is a common condition that causes joints to become stiff and painful. It is most common in the elderly.

With OA of the knee, less synovial fluid which contains hyaluronic acid is produced naturally in the knee joint while synovial fluid acts as the knee's shock absorber and protects cartilage coverings from wear and tear. Gradually, as joint fluid continues to break down and cartilage eteriorates, bones may start to rub against each ther, leading to pain, stiffness, swelling and imited joint activity.

Singjoint® Medical Sodium Hyaluronate Gel is a sterile, non-animal stabilized hyaluronic acid injection designed for the management of knee osteoarthritis (OA). As a high-viscosity viscosupplement, it restores the lubricating and shock-absorbing properties of synovial fluid, helping reduce joint pain and improve mobility.

Widely used as one of the most effective hyaluronic acid shots for knee osteoarthritis, Singjoint® provides long-lasting symptom relief for patients suffering from chronic joint degeneration. These knee gel injections are administered directly into the affected joint cavity, where the hyaluronic acid supplements depleted synovial fluid and improves joint function.

For patients seeking non-surgical treatment options, Singjoint® offers a clinically proven solution among today's most widely used knee pain injections and gel injection for knee treatments.

• Long-lasting pain relief for up to 6 months
• Improves joint lubrication and shock absorption
• Reduces inflammation associated with osteoarthritis
• Enhances mobility and daily activity performance
• Minimally invasive alternative to surgery
• Available in both multi-injection and single-injection protocols
• CE-certified and registered in more than 40 countries worldwide

Singjoint® knee injections help patients regain confidence in movement while delaying the progression of osteoarthritis symptoms.

 

How Do Hyaluronic Acid Shots Work?

Healthy joints contain synovial fluid rich in hyaluronic acid, which acts as a natural lubricant and shock absorber. In osteoarthritis patients, the concentration and quality of hyaluronic acid decrease significantly.

 

Singjoint® hyaluronic acid knee shots replenish this lost lubrication through intra-articular administration. Once injected into the joint space, the gel improves viscosity, reduces friction between cartilage surfaces, and supports smoother joint movement.

 

These injections in the knee for pain are commonly recommended for patients who experience persistent osteoarthritis symptoms despite physical therapy, lifestyle modification, or oral medications.

 

Trusted Manufacturer of Hyaluronic Acid Knee Injections

Singclean Medical is a professional manufacturer specializing in sodium hyaluronate-based medical devices. Our Singjoint® product line has obtained regulatory registrations in more than 40 countries and regions, including Europe, the United Kingdom, Malaysia, Türkiye, Egypt, and South America.

 

With advanced production facilities, strict quality management systems, and flexible OEM/ODM services, Singclean supports global distributors, hospitals, and orthopedic clinics seeking reliable suppliers of hyaluronic acid shots and knee gel injection products.

 

OEM / ODM Solutions for Knee Injections Brands

Beyond supplying finished products, Singclean provides flexible OEM and private-label manufacturing services for global knee injections distributors and medical device brands.

 

Our support includes:

• Custom branding and packaging

• Regulatory documentation support

• Product registration assistance

• Marketing materials and technical training

• Stable long-term manufacturing partnerships

 

Whether you are expanding an existing portfolio or launching a new line of gel shots for knee osteoarthritis, Singclean can provide scalable manufacturing and regulatory support.

 

Singjoint medical sodium hyaluronate gel (for bone joint)

Singjoint medical sodium hyaluronate gel (for bone joint), is non-animal original, with the advantages of high viscoelasticity, lubricity, physical alterability and good biocompatibility. It is a medical polymer extracted and refined by high-tech bio-engineering from streptococcal fermentation metabolites. It is sterile, and free from pyrogenicity, allergy, genetic toxicity, or skin irritation. Due to fermentation production of HA, the product has no risk of being a virus carriers and dissemination medium when extracting animal tissues or organs. This product can be used as an orthopedics agent to improve the joint function. When used for injections in joint cavities, due to its macromolecular characteristic and good viscoelasticity, it stimulates synovium to produce high molecular sodium hyaluronate, which is beneficial for releasing joint pain, increasing mobility, decreasing synovitis and delaying progression of disease.

Singclean® (Medical Sodium Hyaluronate Gel) Viscoelastic Solution For Ophthalmic Surgery

Singclean® (medical sodium hyaluronate gel) viscoelastic solution for ophthalmic surgery, being animal-origin free and of high viscoelasticity, lubricity, physical alterability and good biocompatibility. It is medical polymer extracted and refined by high-tech bio-engineering from streptococcal fermentation metabolites. It is sterile, and free from pyrogenicity, allergy, genetic toxicity, or skin irritation. Due to fermentation production, the product is free from the risk of virus carriers and dissemination medium when extracting animal tissues or organs. Singclean is indicated for helping to prevent or reduce postoperative adhesions after abdominal and pelvic surgery.

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Mechanisms of different types of Ophthalmic surgery）

A. Cataract surgery and IOL implantation

The required amount of SINGCLEAN is slowly infused through a needle or cannula into the anterior chamber. The protective effect of SINGCLEAN as an aid is optimized when the injection is performed prior to cataract extraction and insertion of the lOL and is effective for both intra- and extra-capsular procedures. SINGCLEAN may be applied to lOL prior to insertion. Additional SINGCLEAN can be injected as required to facilitate surgical procedures.

B. Corneal transplant surgery

The corneal button is removed and the anterior chamber filled with SINGCLEAN is at level with the surface of the corneal. The donor graf is then placed on top of the SINGCLEAN and sutured into place. Additional SINGCLEAN can be used as required to aid in surgical procedures.

C. Glaucoma filtration surgery

SINGCLEAN is injected through a corneal paracentesis to restore and maintain anterior chamber volume during the performance of the trabeculectomy. Additional SINGCLEAN can be used as required to aid in the surgical procedures.

D. Secondary lens implantation

Before removing the IOL, a viscoelastic agent is injected into the anterior chamber to maintain the original depth of the anterior chamber, and the IOL is removed from the anterior chamber.

The advantages of Singclean® (medical sodium hyaluronate gel) viscoelastic solution for ophthalmic surgery

Raw material sodium hyaluronate comes from bacterial fermentation, no pyrogen and rejection reaction, with good biocompatibility, etc.

High cleanliness of the production environment, 10,000-level workshop, local 100-level environment, to ensure the safety of the product.

High transparency of the products. Before leaving the factory, each product is tested by lamp test, eliminating any product containing foreign impurities, providing a good vision for surgery.

Automated operation, using Sweden Inova automated filling machine filling, the product does not contact with people.

High molecular weight of 1,000,000~2,600,000 Daltons, shear viscosity ≥100,000 mPa-s, which is conducive to the stable operation of repeated movement of surgical instruments during the surgical process and the reduction of mechanical damage in ultrasound; surgical instruments during surgery and reduce mechanical damage in ultrasound.

Good cohesion, can well maintain the depth of the anterior chamber.

Pre-filled syringe packaging + blister packaging. It can prevent impact/vibration during transportation from affecting the product's sterility barrier.

How to use Singclean® (medical sodium hyaluronate gel) viscoelastic solution for ophthalmic surgery

First expulse the air out of the ophthalmic luer-lock needle , then inject Singclean^® appropriately into eye.

The injected amount must be adapted to the type of surgical procedures.

The administration of Singclean^® should be performed only by trained specialists.

Over tightening may cause the hub to weaken and possibly detach from the syringe. Extrusion of a test droplet is recommended prior to entering eye, and excessive force on the plunger should be avoided.

Comprehensive Surgical Adhesion Barrier Solutions for Postoperative Adhesion Prevention

Postoperative Adhesion is a ubiquitous and often underestimated complication in modern surgery. Despite the evolution of surgical techniques—from open procedures to complex robotic-assisted laparoscopy—the body’s inherent wound-healing response remains the same: the formation of fibrous bands between adjacent organs and tissues. These adhesions can lead to severe long-term clinical sequelae, including chronic pelvic pain, intestinal obstruction, infertility, and life-threatening complications during reoperation.

For healthcare providers, the primary objective is to optimize recovery and minimize readmissions. At Singclean Medical, we provide advanced adhesion barrier products that serve as the cornerstone of effective postoperative adhesion prevention. Our surgical adhesion barrier solutions offer surgeons a precise tool to mitigate the risk of adhesions, ensuring that patient recovery is not hindered by the very healing process intended to restore health.

The Pathophysiology of Surgical Adhesion

 

To understand the necessity of an anti-adhesion barrier gel, it is essential to analyze the biological cascade initiated by surgical trauma.

The Fibrinous Bridge

 

Adhesions are abnormal fibrous connections that form between tissues or organs that are normally separate. They typically arise after surgery as a result of the body’s natural healing response. The process begins with surgical trauma or tissue damage, which triggers an inflammatory response. This leads to increased vascular permeability and the release of inflammatory mediators such as histamine, kinins, and other vasoactive substances.

As a result, fibrin—a protein involved in blood clotting—is deposited at the injured site. Normally, the fibrinolytic system breaks down this fibrin to prevent permanent bonding. However, after surgery, the activity of this system is reduced, disrupting the dynamic balance between fibrin deposition and breakdown. This allows fibrin to accumulate.

Over time, white blood cells, macrophages, fibroblasts, and blood vessels invade the area, leading to local vascularization and the formation of fibrous scar tissue. These fibrous bands can stick adjacent tissues or organs together, causing adhesions. The incidence is high, ranging from 67–93% after general abdominal surgery and up to 97% after open gynecological pelvic procedures.

Adhesions can form within hours of surgery and may lead to complications such as pain, intestinal obstruction, and infertility, depending on their location (e.g., abdominal cavity, pelvic region, tendons, or spine).

The Role of Physical Barriers

 

The implementation of a surgical adhesion barrier is designed to intervene at the precise moment of fibrin deposition. By providing a temporary, biocompatible physical separation, our medical anti-adhesion gel ensures that surfaces remain isolated during the critical healing phase, effectively facilitating postoperative adhesion prevention without impeding the natural restorative process.

Why Global Healthcare Networks Trust Singclean’s Adhesion Barrier Products

 

 

As a B2B leader in medical manufacturing, Singclean Medical recognizes that the requirements for a surgical adhesion barrier are stringent. We offer a comprehensive suite of adhesion barrier products designed to meet the rigorous demands of global operating theaters.

 

 

High-Purity Sodium Hyaluronate Gel

The foundation of our success lies in our high-purity sodium hyaluronate gel. Hyaluronic acid (HA) is a major component of the human extracellular matrix, making it inherently biocompatible. Our proprietary extraction and purification methods result in a hyaluronic acid adhesion barrier that exhibits:

Optimized Absorption Time: Degradation of hyaluronic acid (HA) beyond 7 days will endanger the healing process of peritoneal wounds.

Optimal Degradation Kinetics: The barrier remains intact during the fibrinous phase and is safely resorbed by the body as tissue regeneration concludes.

Zero Cytotoxicity: Minimizing the inflammatory footprint to support delicate postoperative healing.

The advantages of Singclean^® medical sodium hyaluronate gel for anti-adhesion

How to use Singclean^® medical sodium hyaluronate gel for anti-adhesion?

1. Open Singclean^® box and take the product out.

2. Follow the indication, peel-open the blister tray, remove the Singclean^® syringe and place on sterile field.

3. After abdominal and pelvic surgery, inject Singclean^® gel into the cavity to completely cover the surface of the organs.

4. In order to achieve the best adhesion prevention results, the gel should not only be applied to the organs that are operated on but also to cover organs away from the surgical areas as much as possible.

5. The amount of gel in every single use depends on the area of surgical wounds. The maximum dosage regimen is no more than 50mL.

The integration of an anti-adhesion barrier for surgery is indicated across multiple surgical specialties.

Abdominal and General Surgery

In abdominal procedures, the risk of small bowel obstruction is significant. Utilizing a medical anti-adhesion gel during the primary procedure is a cost-effective strategy to avoid secondary, high-risk interventions.

Gynecological and Pelvic Surgery

Pelvic adhesions are a primary cause of secondary infertility and chronic pelvic pain. The application of our absorbable adhesion barrier in myomectomy or endometriosis surgery is clinically recognized as an essential component of postoperative adhesion prevention, preserving reproductive function and patient quality of life.

For medical device distributors and hospital procurement officials, the choice of an adhesion barrier products supplier is a decision based on trust, safety, and compliance.

Regulatory Rigor

Singclean Medical operates under ISO 13485 quality management systems. Our surgical adhesion barrier solutions hold CE 2460 certification, providing the necessary regulatory backing for distribution in European, Southeast Asian, and Latin American markets. We understand the complexities of local health authority registrations and provide comprehensive technical dossiers to our B2B partners to accelerate market access.

Supply Chain Stability

As a primary manufacturer, we control the entire lifecycle of our anti-adhesion barrier gel, from raw material sourcing to terminal sterilization. This vertical integration guarantees:

Consistent Batch Quality: Ensuring the safety profile remains identical for every patient.

Scalable Production: Meeting the volume demands of large hospital chains and national distributors.

Partnering with Singclean for Better Surgical Outcomes

The adoption of postoperative adhesion prevention protocols is not merely a clinical choice; it is a commitment to the long-term well-being of the patient. By integrating high-quality adhesion barrier products into standard surgical protocols, hospitals can decrease reoperation rates, reduce post-surgical complications, and demonstrate a commitment to clinical excellence.

Singclean Medical invites medical device distributors and procurement leaders to partner with us in delivering superior surgical care. Our surgical adhesion barrier solutions are more than products—they are a testament to our dedication to the advancement of surgical safety worldwide.

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Singclean Medical is one of the leading medical sodium hyaluronate gel manufacturers and suppliers in China. with many highly qualified staff and advanced technology, we warmly welcome you to wholesale our quality medical sodium hyaluronate gel at competitive price which has no doubt to bring you many benefits.