What to Know about Knee Gel Injections and Cortisone Shots

Jan 28, 2026

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Knee gel injections and cortisone shots help people with sore knees. Doctors use cortisone shots more than knee gel injections. A big study showed most people picked cortisone shots. Both treatments can lower pain and help you move better.

 

Treatment Type

Benefits

Limitations

Knee Gel Injections

Relief can last up to six months

It may take weeks to feel better

Cortisone Shots

Relief starts in a few days

Relief lasts about three months

 

People should talk to their doctor before they choose a treatment.

 

Knee-Gel-Injections-and-Cortisone-Shots

 

Key Takeaways

Knee gel injections can help for up to six months. They are a good choice for mild or moderate arthritis. Cortisone shots work fast, often in 1 to 3 days. But they usually help for only about three months. Always talk to your doctor to pick the best treatment for your knee pain. Follow your doctor's advice after you get injections.

 

Knee Gel Injections and Cortisone Shots Overview

What Are Knee Gel Injections

Knee gel injections help people with arthritis in their knees. Doctors use hyaluronic acid to add gel to the joint. Some new types use platelet-rich plasma or stem cells. These injections are FDA-approved for knee arthritis when other treatments do not help.

 

Ingredient/Compound

Description

Hyaluronic Acid

This is a natural part that helps joints move smoothly.

PRP (Platelet-Rich Plasma)

It uses the patient's blood to help the knee heal.

Stem Cell Injections

These try to fix damaged tissue by making new cells grow.

 

How Knee Gel Injections Work

Knee gel injections help the knee move easily. Hyaluronic acid makes the fluid thicker and protects the cartilage. The gel covers the inside of the knee and lowers friction. It also helps with pain and swelling. It may help the body make more joint fluid.

Makes joint fluid slippery again

Lessens pain and swelling

Might slow down damage to the joint

 

Who Should Consider Knee Gel Injections

Doctors suggest these injections for people with mild or moderate arthritis. They work best if you still have some cartilage left. People who tried exercise, weight loss, or pain medicine but still hurt may get relief. If you have severe arthritis, these injections may not help much.

 

What Are Cortisone Shots

Cortisone shots use steroid medicine to treat knee pain. They help with many problems, like osteoarthritis. The shot has a corticosteroid and a local anesthetic for fast relief.

 

Component

Description

Corticosteroid

This medicine gives long-lasting pain relief for the knee.

Local Anesthetic

It helps you feel better right away during the shot.

 

How Cortisone Shots Work

Cortisone shots lower swelling and pain by calming the immune system. The steroid stops chemicals that cause inflammation. This makes pain go down and helps you move your knee.

 

Who Should Consider Cortisone Shots

Doctors recommend cortisone shots for people who tried other treatments but still have pain. These shots are good for quick relief or if other treatments stopped working.

 

Treatment Type

Indication

Knee Gel Injections

FDA-approved for treating knee arthritis.

Cortisone Shots

Good for treating swelling problems, like osteoarthritis of the knee.

 

Relief, Effectiveness, and Safety Compared

How Fast Relief Starts

People want to know how soon they will feel better after these treatments. Cortisone shots work fast for most people. Many feel less pain in just 1 to 3 days. Knee gel injections take more time to help. You might wait 4 to 6 weeks to feel the full effect.

 

Treatment Type

Average Time to Pain Relief Onset

Cortisone Shots

1-3 days

Knee Gel Injections

4-6 weeks

 

How Long Relief Lasts

How long the pain goes away is important when picking a treatment. Cortisone shots help for a few weeks or up to three months. Some people need another shot if their pain comes back. Knee gel injections, also called viscosupplementation, can last longer. Many people feel better for three to six months after getting them. Hyaluronic acid injections are a kind of knee gel injection that may last longer.

Cortisone shots: Relief lasts about 3 months.

Knee gel injections: Relief can last up to 6 months.

 

Effectiveness for Different Knee Conditions

How well these treatments work depends on your knee problem. Cortisone shots are good for strong pain and swelling. They help people with osteoarthritis and can help with rheumatoid arthritis too. Sometimes, physical therapy works better for some people. Knee gel injections work best for dull, aching pain from mild or moderate arthritis. They may not help much if your joint is very damaged.

Cortisone shots: Best for quick relief and swelling.

Knee gel injections: Better for long-lasting relief in mild to moderate arthritis.

If you have high blood pressure or high blood sugar, knee gel injections may be safer than cortisone shots.

A new study showed that using both cortisone and hyaluronic acid together can give fast and long-lasting relief.

 

Safety and Side Effects

Both treatments are safe for most people, but side effects can happen. Right after the shot, you might feel pain or discomfort where you got the injection. Swelling or redness can also show up. Some people feel warm or flushed. Over time, cortisone shots can make cartilage wear down or raise blood sugar, especially if you have diabetes. They can also make bones and tissues weaker if used too much.

Common side effects:

Pain at the injection site

Swelling or redness

Feeling warm or flushed

 

Long-term risks:

Cartilage damage (mostly with cortisone shots)

High blood sugar

Weaker bones or tissues

 

What to Expect After Each Injection

What you do after the shot helps you heal. After knee gel injections, rest your knee and do not do hard activities for at least 24 hours. Use ice or heat if your doctor says it is okay. Keep the area clean and dry. Do not swim or soak in water for two days. Try not to stand for a long time or lift heavy things right after the shot. Keep doing other treatments for arthritis, like medicine or physical therapy.

After cortisone shots, you can walk and do normal things, but do not do hard exercise for about 48 hours.

 

Activity Type

Recommendation

High level activities

Wait 48 hours

Routine activities (walking)

Allowed after injection

 

Choosing the Right Option

Picking between cortisone shots and knee gel injections depends on what you need. Think about your age, how bad your knee pain is, and your health. Cortisone shots work fast but may not last as long. Knee gel injections take longer to work but can last longer. The quality of the gel and the type of arthritis also matter.

Factor

Description

Age

May change how well the treatment works

Severity of Condition

Bad cases may need different treatments

Quality of Gel Injected

Can affect how well knee gel injections work

Doctors often use cortisone shots for short-term relief. Some rules support hyaluronic acid injections, but others do not. Talk to your doctor about which treatment is best for your knee. Always ask about side effects and how to care for your knee after the shot.

 

Knee gel injections can help if other treatments do not work.

Cortisone shots help fast, but the relief does not last long.

Not everyone feels better for a long time with these treatments.

Staying at a healthy weight and doing gentle exercise is good for your knees.

 

FAQ

How painful are knee gel injections or cortisone shots?

Most people feel a small pinch when they get the shot. Some people have a little soreness after. Doctors use numbing medicine to make it hurt less.

 

Can I drive after getting a knee injection?

You can usually drive after a knee injection. If you feel dizzy or weak, wait until you feel okay before driving.

 

Are these treatments covered by insurance?

Treatment Type

Usually Covered by Insurance?

Knee Gel Injections

Yes, if your doctor says you need it

Cortisone Shots

Yes, most of the time