Understanding Hyaluronic Acid and Its Role in Joint Health
Hyaluronic acid is a natural mucopolysaccharide found in synovial fluid - the lubricant and shock absorber of healthy joints. In patients with osteoarthritis, the natural HA concentration and molecular weight decline, leading to pain, stiffness, and reduced mobility.
To restore normal joint function, hyaluronic acid injections-also known as viscosupplementation therapy - are administered to supplement and replace the degraded synovial fluid, reducing friction and improving joint mobility.
Types of Hyaluronic Acid Injections
Different types of HA injections vary in molecular weight, concentration, and cross-linking structure. These factors determine the viscosity, durability, and therapeutic duration of the product.
1. Low Molecular Weight Hyaluronic Acid
Low molecular weight HA (typically below 1 million Daltons) is less viscous and easier to inject. It spreads rapidly in the joint cavity, providing quick pain relief but shorter-lasting results.
- Key Benefits: Fast onset of action, suitable for mild osteoarthritis.
- Limitation: Requires multiple injections to maintain efficacy.
2. High Molecular Weight Hyaluronic Acid
High molecular weight HA (over 1 million Daltons) mimics the viscoelasticity of healthy synovial fluid more effectively. It enhances joint lubrication, cushions impact, and stimulates endogenous HA production by synovial cells.
- Key Benefits: Prolonged retention in the joint, improved protection of cartilage.
- Applications: Ideal for moderate to severe OA where longer-term pain relief is desired.
3. Cross-linked Hyaluronic Acid
Cross-linked HA is chemically modified to enhance molecular stability and resistance to degradation. This structure provides the highest viscosity and the longest-lasting therapeutic effect, often requiring only one injection for up to six months of relief.
- Key Benefits: Single-dose convenience, durable viscoelasticity.
- Applications: Suitable for patients seeking a faster recovery and sustained joint function.
Singjoint®: Optimized Viscosupplementation for Every Need
Singjoint® Medical Sodium Hyaluronate Gel from Hangzhou Singclean Medical Products Co., Ltd. is developed using non-animal sourced hyaluronic acid from streptococcal fermentation metabolites. Its excellent biocompatibility, purity, and molecular control ensure minimal immune response and high patient comfort.
Singjoint® 10–12 mg/ml: Balanced Molecular Design
- Molecular Weight: ≥ 1.0M Daltons
- Concentration: 10–12 mg/ml
- Regimen: Series of 3–4 injections
- Features: Intermediate viscosity for enhanced lubrication, gradual pain reduction, and stimulation of natural HA synthesis.
- Ideal For: Patients with mild to moderate OA or those who prefer gradual treatment cycles.
Singjoint® 20 mg/ml: High-Concentration, Long-Lasting Relief
- Molecular Weight: ≥ 1.6M Daltons
- Concentration: 20 mg/ml
- Regimen: Single injection
- Features: Higher viscosity and superior viscoelastic protection, providing pain relief for over six months.
- Ideal For: Active patients requiring a fast recovery and durable joint cushioning.
These different models meet the diverse needs of orthopedic patients, offering both cost-effective multi-dose options and premium single-injection convenience.
Why Choose Singjoint®?
Singjoint® stands out through scientific precision, enhanced comfort, and long-term efficacy:
- Higher Concentration, Stronger Support – Up to 102% higher concentration than competing brands, ensuring robust joint cushioning.
- Superior Biocompatibility – Osmolality (313 mOsm/kg) closely matches human physiology, reducing injection discomfort.
- Longer-Lasting Performance – Kinetic viscosity 5–10 times higher than competitors, with molecular weight nearly double, resulting in longer degradation time and sustained relief up to six months.
These attributes make Singjoint® a trusted viscosupplementation solution for orthopedic professionals worldwide.
Applications in Orthopedic Treatment
Hyaluronic acid injections are particularly effective for:
- Knee osteoarthritis – Reduces pain, stiffness, and improves joint flexibility.
- Shoulder and hip osteoarthritis – Restores smooth movement and protects cartilage.
- Post-arthroscopic recovery – Supports healing by improving lubrication and reducing inflammation.
By replicating natural synovial fluid properties, HA injections like Singjoint® delay or reduce the need for surgical joint replacement.
Conclusion
Different types of hyaluronic acid injections serve diverse orthopedic needs, depending on their molecular structure and concentration. With Singjoint®'s scientifically engineered formulations, patients can experience effective, comfortable, and long-lasting relief from osteoarthritis pain - supporting healthier, more active lifestyles.
About Singclean Medical
Founded in 2003, Hangzhou Singclean Medical Products Co., Ltd. is a leading manufacturer of hyaluronic acid-based medical devices for aesthetics, ophthalmology, and orthopedics. With over two decades of R&D expertise, Singclean is committed to innovation, safety, and global healthcare advancement.