Introduction
In modern ophthalmic surgery, viscoelastic substances are indispensable materials that protect delicate ocular tissues, maintain intraocular space, and facilitate the manipulation of intraocular lenses. These specialized polymer solutions - collectively known as Ophthalmic Viscoelastic Devices - are widely used in procedures such as cataract extraction, corneal transplantation, and glaucoma surgery.
Among various viscoelastic materials, sodium hyaluronate and carboxymethylcellulose are the most prominent due to their superior lubricating and protective properties. This article explores their composition, classification, and key functions in ophthalmic practice, with a focus on the technological advantages of Singclean's medical-grade OVDs.
Composition of Viscoelastic Substances
Viscoelastic substances are biopolymer-based gels that exhibit both viscous and elastic behavior-enabling them to cushion, lubricate, and stabilize intraocular tissues during surgery.
Sodium Hyaluronate
Sodium hyaluronate is a linear macromolecular mucopolysaccharide composed of repeating disaccharide units of glucuronic acid and N-acetylglucosamine. In Singclean's OVDs, HA is derived from bacterial fermentation, ensuring high purity, non-pyrogenicity, and excellent biocompatibility.
Each milliliter of Singclean OVD (15 mg/mL) contains highly purified sodium hyaluronate (molecular weight between 1,000,000 and 2,600,000 Daltons) dissolved in a balanced sodium phosphate buffer with an osmotic pressure of 270–350 mOsm/kg-closely mimicking physiological conditions.
Carboxymethylcellulose
CMC, another commonly used viscoelastic substance, is a cellulose derivative that provides superior coating and dispersive properties. When combined with HA, it enhances the corneal endothelial protection and intraocular visibility during phacoemulsification and IOL insertion.
Classification: Cohesive vs. Dispersive OVDs
Viscoelastic agents are typically divided into two categories:
Cohesive OVDs: possess high viscosity and molecular weight, allowing easy injection and removal. They are ideal for maintaining anterior chamber depth and stabilizing tissue planes.
Dispersive OVDs: have lower viscosity and spread easily across ocular surfaces, providing extended protection for the corneal endothelium.
Singclean OVD is classified as cohesive, making it particularly effective in cataract surgery, where maintaining a stable chamber and clear visual field is crucial.
Key Clinical Functions
A. Protection of Ocular Tissues
Viscoelastic substances shield the corneal endothelium from mechanical trauma and ultrasonic energy during phacoemulsification, significantly reducing postoperative corneal edema.
B. Space Maintenance
Cohesive viscoelastics like Singclean's OVD maintain the anterior chamber depth during IOL insertion, preventing collapse and ensuring precise lens positioning.
C. Lubrication and Debris Removal
Their rheological properties allow smooth instrument movement, minimizing friction between tissues and helping remove blood clots and tissue fragments efficiently.
D. Wound Healing Support
Viscoelastics aid in wound healing by preventing tissue adhesion and supporting natural tissue recovery post-surgery.
Applications in Ophthalmic Surgery
Viscoelastic substances are extensively used in the following procedures:
Cataract Surgery & IOL Implantation: Maintains anterior chamber stability and protects intraocular tissues during lens removal and replacement.
Corneal Transplant Surgery: Acts as a cushion and medium for the corneal graft.
Glaucoma Filtration Surgery: Helps restore and maintain anterior chamber volume during trabeculectomy.
Secondary Lens Implantation: Facilitates safe IOL removal and reinsertion.
Clinical studies confirm that low-to-moderate concentration OVDs effectively balance corneal protection and intraocular pressure management, ensuring optimal postoperative outcomes.
Singclean's Technological and Quality Advantages
Produced in a 10,000-level cleanroom with automated Swedish Inova filling systems, Singclean OVDs guarantee sterility, transparency, and stability. Each syringe is terminally sterilized and lamp-tested to eliminate any impurities.
The pre-filled syringe with blister packaging ensures product integrity during transport and clinical handling. Global feedback from ophthalmologists confirms Singclean OVD's excellent performance and user satisfaction.
Global Market Outlook
With cataract and glaucoma surgeries on the rise, the global ophthalmic viscoelastic devices market is projected to reach USD 1.27 billion by 2028 with a CAGR of over 10%. This surge underscores the increasing demand for biocompatible and high-performance OVD.
About Singclean Medical
Hangzhou Singclean Medical Products Co., Ltd. is a leading Chinese manufacturer of sodium hyaluronate-based medical materials. With CE-certified and ISO13485-compliant facilities, Singclean delivers innovative solutions for ophthalmology, orthopedics, and aesthetics. Its ophthalmic viscoelastic device exemplifies the company's commitment to safety, innovation, and global healthcare excellence.