Bone Repairing Materials

SingJoint Bovine Type I Collagen & β-Tricalcium Phosphate Composite Ceramic Bone Repairing Materials

Structural Adaptability: Collagen fibers and bioceramics form the product's unique three-dimensional porous structure.

Customizable Molding: After hydration, it conforms closely to the bone surface and can be shaped as needed.

Dual Efficacy:
Collagen induces bone regeneration, while β-tricalcium phosphate provides a creeping substitution scaffold,
enabling osteoconduction.

Safe & Efficient:

Biodegradable and absorbable, with a degradation rate that matches new bone regeneration.

Animal study:
New Zealand white rabbits were used as experimental subjects to undergo posterior two-level spinal fusion. The animals were randomly divided into three groups and implanted with either a moldable artificial bone repair material(SingJoint), β-TCP ceramic granules, or autogenous iliac bone, respectively. At 4 and 12 weeks post-surgery, the animals were sacrificed and sampled for evaluation, including X-ray examination, micro-CT, biomechanical testing, calculation of bone deposition rate, and histological assessment.

Conclusion:
The product demonstrated superior efficacy over -TCP in posterior two-level spinal fusion and shows promise as a substitute for autogenous bone in the treatment of spinal disorders.

Clinical Application

Department of Stomatology

1. Maxillofacial bone defect reconstruction
2. Defect filling after bone cystcurettage
3. Extraction socket preservation

Department of Orthopedic Trauma

1. Old fracture
2. Osteoporotic fracture
3. Delayed bone union & bone defect
4. Fresh fracture requiring internal fixation
5. Bone lengthening/bone transport surgery
6. Orthopedic corrective surgery

Joint Surgery Department

1. Total knee arthroplasty
2. Hip joint preservation therapy
3. Knee joint preservation therapy
4. Joint revision surgery

Contraindicated for patients with systemic/local severe infection, uncontrolled severe diabetes, severe hepatic/renal insufficiency or immunodeficiency.
Not for patients with confirmed allergy to bovine-derived materials or collagen products.
 

(1) Cut or tear open the outer packaging, and remove the inner packaging under aseptic conditions;
(2) Open the inner packaging under sterile conditions;
(3) A physician with appropriate expertise, according to the shape requirements of the bone graft material for the patient's bone defect site, uses a sterile scalpel or rongeur to trim the product to the appropriate size and shape, moistens it with normal saline or the patient's own blood, fills it into the defect site, and covers it with the surrounding soft tissue.
The specific implantation method for each site is the same as that of traditional autologous bone grafting. The amount used is determined according to the defect site, an d the maximum amount shall not exceed 80 cm².

Source of literature:
Lu Y, Li M, Long Z, DiYang, Guo S, LiJ, Liu D, Gao P, Chen G, Lu X, Lu J, WangZ. Collagen/β-TCP composite as a bone-graft substitute for posterior
spinal fusion in rabbit model：a comparison study. Biomed Mater. 2019 May 17;14(4):045009.

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