SingJoint®: Dedicated to Long-Term Pain Relief of OA
The science of high concentration meets exceptional biocompatibility. Provide your patients with up to 6 months of sustained relief from osteoarthritis knee pain with our premium, non-animal sourced HA gel.
Understanding Osteoarthritis: The Need for Effective Viscosupplementation
Osteoarthritis (OA) is a degenerative, progressive disease. In a healthy knee, synovial fluid-rich in hyaluronic acid (HA)-cushions and lubricates the joint. As OA progresses from mild to severe, the quality and quantity of this natural HA break down, leading to pain, stiffness, and reduced mobility.
For patients with mild to moderate OA, conservative therapies often fall short, and surgical options may be premature. This is where viscosupplementation with exogenous HA plays a critical role. By supplementing the pathological synovial fluid, HA injections can:
Reduce pain and inflammation
Improve joint function and lubrication
Potentially delay the need for total knee replacement (TKR)
Why Hyaluronic Acid? The Core Component of Synovial Fluid
HA is the most important, natural mucopolysaccharide found in your joints. Its unique viscoelasticity, lubricity, and shock-absorbing properties are entirely dependent on the concentration and molecular weight (MW) of HA.
Proven Benefits of Exogenous HA Injection：
Enhances chondrocyte HA synthesis and promotes cartilage regeneration¹
Reduces proinflammatory mediators and matrix metalloproteinases involved in OA pathogenesis¹
¹ Migliore A, Procopio S. Effectiveness and utility of hyaluronic acid in osteoarthritis. Mini Rev Clin Cases Mineral Bone Metab. 2015;12(1):31–33.
Why Choose SingJoint®? Where Science Meets Comfort & Longevity
SingJoint® is a colorless, transparent, high-purity HA gel derived from streptococcal fermentation metabolites (EP-approved, non-animal sourced). It is indicated for treating OA knee symptoms by restoring the rheology of the joint environment.
1. Higher Concentration, Stronger Structural Support
SingJoint is formulated with a 102% higher concentration than a competing Turkish brand product.
*Example: For a 3.0ml-30mg/ml specification, the competing product delivers an actual HA content of only 78.39mg (90*87.1%).*
SingJoint® delivers its full, labeled concentration for predictable, powerful efficacy.
2. Superior Biocompatibility for a Comfortable Experience
Osmolality: 313 mOsm/kg - closely matching that of human synovial fluid.
Result: Minimal tissue irritation, reduced injection-site discomfort, and smooth integration for natural-feeling relief.
3. Longer-Lasting Performance that Delays Surgery
Kinetic Viscosity: 5 to 10 times higher than competing products.
Viscosity-Average Molecular Weight: Nearly double that of competing products.
Clinical Outcome: Slower degradation, extended intra-articular residence time, and efficacy lasting up to 6 months (vs. 3-4 months for many alternatives).
specification
| Feature | SingJoint® Standard Series | SingJoint® Single-Injection |
|---|---|---|
| HA Concentration | 10mg/ml or 12mg/ml | 20mg/ml (highly concentrated) |
| Molecular Weight | ≥ 1.0M Daltons (Ideal MW) | ≥ 1.6M Daltons (Ideal MW) |
| Injection Regimen | Series of 3 or 4 injections | Single injection |
| Pain Relief Duration | Up to 6 months | Over 6 months |
| Ideal For | Patients preferring cost-effective, staged treatment | Patients requiring faster recovery and fewer clinic visits |
Singjoint Application
Singjoint® is administered by intra-articular injection.Asceptic injection procedure shall be followed.
Fix a suitable gauge to the syringe lever lock.
The required amount of product is injected into the selected joint space.
The administration of Singjoint® should be performed only by trained specialists.
If joint effusion is present, it should be aspirated before injection.
Discard the syringe and needle after single use.The dosage regimen is injecting into the affected synovial joint space just once
Quality Assurance: From Raw Material to Finished Product
SingJoint is manufactured in a Class 10,000 (ISO 7) cleanroom under rigorous quality control. Our process ensures zero immunogenicity, excellent biodegradability, and consistent batch-to-batch performance.
Raw Material: EP-approved, non-animal sourced.
Key Processes: Fermentation -> Purification -> Mixing -> Sterilization -> Aseptic Filling -> Visual Inspection -> Final Packaging & Storage.
Purification
Filling
Sterilization
Appearance Inspection
Inner Packing
Certification
Partner with Singclean Medical: Customization & Supply
Singclean Medical offers full OEM support to help you build or expand your brand in viscosupplementation.
What you can customize:
Device & packaging
Instruction manual
Product label & carton design
Accessories
Why partner with us?
Low MOQ to support market testing.
Professional in-house engineering and design teams.
Rapid sample and order turnaround.
FAQ
Q: 1. Is SingJoint® safe for long-term use?
A: Yes. As a non-animal, bio-fermented HA, SingJoint® is non-immunogenic and fully biodegradable, offering an excellent safety profile for repeated treatment cycles.
Q: 2. How does SingJoint® improve patient compliance?
A: Its excellent biocompatibility minimizes injection discomfort, and its long-lasting efficacy (up to 6 months) reduces the frequency of injections required per year.
Q: 3. Can I get samples for clinical evaluation before placing a bulk order?
A: Absolutely. We encourage qualified partners to request samples for clinical or performance evaluation.
Q: 4. How do I start a custom order (OEM/private label)?
A: Simply contact our team at marketing@hzxhe.com with your requirements. We will manage the entire process from label design to final production.
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